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Publications
*Corresponding author
Wilkinson DJ*. The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing? Osteoarthritis and Cartilage. 2022 Apr 2;S1063-4584(22)00698-7
Wilkinson DJ* and Young DA. Joint tissue destruction and proteolysis. Rheumatology Chapter 14 (Textbook; 8th Edition). (2022) [Accepted In Press].
Wilkinson DJ*, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MdC, Janciauskiene S, Refaie R, Rankin KS, Young DA, Rowan AD. Matrix metalloproteinase-13 is fully activated by neutrophil elastase, and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS J;289(1):121-139.*(Corresponding Author)
Wilkinson DJ*. Serpins in cartilage and osteoarthritis: what do we know? Biochem Soc Trans. 2021. Apr 30;49(2):1013-1026.
Yamamoto K, Wilkinson DJ, Bou-Gharios G, Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. Calcified Tissue Int. 2021. 109(3):277-290.
Falconer AMD, Chan CM, Gray J, Nagashima I, Holland RA, Shimizu H, Pickford AR, Rowan AD, Wilkinson DJ*. Collagenolytic matrix metalloproteinases antagonise proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover. J Biol Chem. 2019 28;294(26):10266-10277.
Young DA, Barter MJ, Wilkinson DJ. Recent advances in understanding the regulation of metalloproteinases. F1000Res. 2019 Feb 18;8.
Wilkinson DJ*, Arques Mengual MC, Huesa C, Rowan AD. The role of serine proteinases in cartilage extracellular matrix turnover: Implications for therapeutics. Br J Pharmacology. 2019 Jan;176(1):38-5.
Macdonald CD, Falconer AMD, Chan CM, Wilkinson DJ, Skelton A, Reynard L, Europe-Finner GN, Litherland GJ, Rowan AD. Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes. PLoS One 2018 Nov 15;13(11):e0207240
Baker J, Falconer AMD, Wilkinson DJ, Europe-Finner GN, Litherland GJ, Rowan AD. Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLoS One 2018. 13(4):e0195864
Rowan AD, Young DA, Wilkinson DJ. Tissue Destruction and Repair. Rheumatology Chapter 17 (Textbook; 7th Edition). 2018.
Wilkinson DJ, Desilets A, Lin H, Charlton S, Arques M.C, Falconer A, Bullock C, Hsu YC, Birchall K, Thompson P, Ferrell WR, Lockhart J, Plevin R, Zhang Y, Blain E, Lin SW, Leduc R, Milner JM, Rowan AD. The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover. Scientific Reports. 2017 Dec 1;7(1):16693.
Wilkinson DJ, Hui W, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets AR, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, and Rowan AD Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo: Promotion of osteoarthritic cartilage damage by multiple mechanisms. Arthritis and Rheumatol. 2017 69(8):1601-1611
Chan CM, Macdonald CD, Litherland GJ, Wilkinson DJ, Skelton A, Europe-Finner GN, Rowan AD. Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation. J Biol Chem. 2017. Feb3:292(5):1625-1636
Radwan M, Wilkinson DJ, Hui W, Destrument AP, Charlton SH, Barter MJ, Gibson B, Coloumbe J, Gray DA, Rowan AD, Young DA. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. Ann Rheum Dis 2015. 74(8):1580-7
Litherland GJ, Hui W, Elias MS, Wilkinson DJ, Watson S, Huesa C, Young DA, Rowan AD. Glycogen synthase kinase-3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis. Arthritis Rheumatol. 2014. 66 (8):2175-87
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